[sardonically, on wrapping Series 3 of Buffy the Vampire Slayer] I was just relieved they weren't going to do the fifth year of high school. [A&E Biography: Buffy the Vampire Slayer]

[She was asked in a May 6, 2003 interview by Fred Topel how she developed the "Willow voice"] I sort of got her voice when I was auditioning. I was sitting in the parking lot looking at the material, and I didn't have it, I didn't have it. Then there was one particular line which, from there on, I was like, "Okay, I know how I want to play this character."

Asked in a May 6, 2003, interview by Fred Topel what might be her final thoughts on playing Willow Rosenberg, Hannigan answered, "Oh, I'm going to miss everything. It's been the most amazing and significant job of my life obviously and I'll always have it near and dear to my heart. I'm so grateful and appreciative that I worked with the best crew and the best writers and producers and cast and I love them all." The follow-up interview question was: "What would you like the fans to do with an extra hour in their schedule?" Hannigan replied firmly: "Read."

Nerds are far more interesting human in later life. - on the varying times of "blossoming" for individuals.

You need to suffer to be interesting.

It's like walking around a history book. You have all these beautiful buildings that were built before 1980. - on London.

[on her role as the witch "Willow", crossing over from Buffy the Vampire Slayer (1997) to act in the episode Angel: Orpheus (2003) on the series Angel (1999), where her fiancé, Alexis Denisof, is a regular:] "I finally get to spend a day with my honey, so that's really nervous coming in. I had butterflies in my stomach. I don't know why I was so nervous -- maybe because I don't know how to pronounce half the lines I have to say today. They're in some made-up language".

"It was great for a change to share a week's work, rather than being on different projects. With the hours Alexis and I spend on set, you can tend to pass like ships in the night. Weekends, however, are great because we can share precious time together. But when we're at home, I promise you, we certainly don't talk about vampires or suck each other's blood for tea" [on playing the season 4, episode 15, role of "Willow" as a crossover on Angel (1999) June 4, 2003].