Andrew O'Donnell studied Acting and Performance at Langside College and later went on to graduate from the University of the West of Scotland with a degree in Contemporary Screen Acting. In 2011, he made a cameo appearance in the film Perfect Sense (2011) as a night clubber. In the same year, O'Donnell provided the voice for the characters of Harbour Master and the Cameraman in the Scottish feature film In Search of La Che (2011). It was on this film where he first met Chris Quick. After discussing the problems of making a feature film together, Quick invited O'Donnell to collaborate on an idea he had about an online database that would bring industry professionals closer together. The pair put the wheels in motion and on 31 October 2011, launched the Glasgow Filmmakers Alliance.The following year, he landed the role of Jimmy Guinness in the film The Greyness of Autumn (2012). O'Donnell's performance was widely praised by critics with John McArthur of Moviescramble saying 'His scene was laugh out loud funny and still raises a smile when thinking about it.' Later that year he performed in a production of Harold Pinter's The Dumb Wait alongside Jerry Taylor.In September 2013, O'Donnell became the head of sales and new business for the Roundsquare Roastery coffee company in Ayr.