Odho was born in Karachi, Pakistan on the February 12, 1968. She is married to Samar Ali Khan, and has three children. She started her professional life as a make-up artist and hairstylist in 1989. While working as a make-up artist for various advertising agencies in Karachi, she was discovered by television personality, Anwar Maqsood. She starred in his play, "Sitara Aur Mehrunissa" in 1993; the role turned her into a household name in Pakistan.She lives in the UAE and Pakistan. She is engaged in philanthropic activities. She is also the ambassador for the campaign on awareness of breast cancer in Pakistan.