Anastasi's notoriety first began when he was selected for BBC's Drama series submission 2014 and was, soon after, chosen from a high number of applicants for comedy screen writing training with the BFI. He made his name for himself as a writer with his first feature, Madness in the Method, which stars such actors as Jason Mewes, Kevin Smith, Danny Trejo and Stan Lee. His experience ranges from working on stage production,The Children's Monologues, with Danny Boyle, to working with Thin Man Films and Mike Leigh's own trusted crew. Although Anastasi's time is mainly devoted to screenwriting, he does make acting appearances as per his performance in ITV's Grantchester's season 2 finale.