Diego Serrano was born in Quito, Ecuador. During his childhood, he ironically did not watch television but rather played soccer. Other hobbies include playing golf, bike riding, hiking and dancing. At 18 he won a Star Search (1983) modeling contest, and soon after started playing Tomas on Another World (1964). His big break came in 2000, when he starred alongside star Jennifer Love Hewitt on the Fox television series Time of Your Life (1999). The show garnered him plenty of attention, and he was voted as one of the 10 New Faces to Watch. Whole growing up, he said that he was inspired by the careers John Malkovich and Meryl Streep.