He started his career with a small role in the film "Ginger e Fred" by Federico Fellini, subsequently played important roles in various films and television movies such as "Arabella l'angelo nero" and "Allullo drom - L'anima zingara". In 1994 he was chosen by Tinto Brass as the protagonist of the film "L'uomo che guarda", based on the eponymous novel by Alberto Moravia. The film caused quite a stir because for the first time showed real male genitalia erected instead of the usual prostheses and just Casale performed in a long scene of erection. In the following years he took part in some mini-series including "La famiglia Ricordi" and the "Caraibi" and also had film roles in "Ivo il tardivo", "Jolly Blu" and "Come mi vuoi", in which he played a transvestite Joy. Married to the Princess Victoria Odescalchi, Casale has abandoned the scenes after marriage.