Frank Infante was born in New York. His professional career as a musician began in the early 1970s when he started to play guitar in the band Sniper and later in rock/blues groups like World War III and Elegant End. Infante first began to play bass guitar with Blondie from 1977, playing on Plastic Letters (1978), but not appearing on the cover. He switched to the guitar shortly after when Nigel Harrison joined the band. Blondie struggled in the first few years, but eventually rose to stardom with the release of the album Parallel Lines (1978), which was a platinum selling record in the United States and the UK. Infante continued to play in Blondie until the band broke up in 1983. He did not rejoin the band when the reformed in the late 1990s, but instead went on to perform with other well known artists like Joan Jett, Iggy Pop and the New York Dolls. He continues to perform and record with the band Infante's Inferno.