Langdon first performed when he ran away from home at the age of 12-13 to join a travelling medicine show. In 1903 he scored a lasting success in vaudeville with an act called "Johnny's New Car" which he performed for twenty years. In 1923, he signed with Principal Pictures as a series star, but transferred to the Mack Sennett Studio when Mack Sennett bought the contract. Early in his film career, he had the good fortune to work regularly with the young Frank Capra. The two developed a unique character of an innocent man-child who found himself in dramatic and hazardous circumstances with only providence and good luck making him come out on top. This character clicked with the public and Langdon enjoyed a streak of artistic and commercial successes using it with Capra's direction. Unfortunately, he began to take the praise of his talent too seriously and broke with Capra so he could hog all the glory himself with his films. This proved to be a disastrous mistake as his first film "Three's a Crowd", a sickeningly sentimental film that plainly showed that he did not even approach the talent and skill of Capra which was needed to keep his character style viable. It has been also speculated the public was getting tired of Langdon's character, which contributed to Langdon's first solo film being an artistic and commercial failure. That film was the first in a series of bombs that ruined Langdon's career and relegated him to minor films from third string companies for the rest of his life.