Margaret McWade born in Illinois in 1872. In vaudeville, during the 1890s, she met Margaret Seddon. The two teamed up in a double act billed as the "Pixilated Sisters". She later appeared most often as spinsters or mothers in many films, first under contract to the Edison Film Company under the direction of Ashley Miller in The Drama of Heyville (1914), starring Marc McDermott, followed by the Vitagraph Film Company.She may have been best-remembered for playing the role of Mrs. Challenger with Wallace Beery as Professor Challenger in 1925's Le monde perdu (1925), made with the First-National Film Company. She was mostly seen in minor roles in many talkies until her last film before retiring, George Cukor's Une femme qui s'affiche (1954), starring Jack Lemmon and Judy Holliday.