Reneau began her professional mixed martial arts career in 2010. After winning several professional fights she attempted to try out for The Ultimate Fighter 18. However, she was allegedly told by UFC brass that she was too old to be a contestant on the show, but to keep pressing on and to win a couple of more fights. On the heels of her submission victory over Maureen Riordan in July 2014 at Resurrection Fighting Alliance 16, she was signed by the UFC.