Sarah Colley studied dramatics in Belmont College in Nashville, intending to be a serious actress, but while touring with an Atlanta company, she created the Minnie Pearl character that became her life's work. Her first Grand Old Opry appearance was on the radio show in 1940, followed by 27 years of touring. She was diagnosed with cancer in 1985, and recovered after a double mastectomy. A mild stroke in June 1991 forced her to give up performing.