Naomi Chance attended Central School of Drama. After a short period in repertory and on tour she obtained a small screen part and followed this with some starring roles in films opposite some American stars appearing in British films. She became well-known on British TV for her appearances as Amelia Huntley in The Newcomers (1965). Her second husband was a retired naval surgeon, with whom she lived in Devon for many years. Her final appearance was in 1976. She still had friends in the business in London. She frequently went to visit them and wanted to act again, but they told her to forget it. Anthony Hinds, who produced some of her early films, said of her, "She is very talented, but her trouble is she won't sell herself."