Rita Macedo was the daughter of novelist Julia Guzmán. She began acting in the 1940s. Macedo was first married to writer 'Carlos Fuentes'; then to producer Luis de Llano and their children are actress/singer/producer Julissa, and TV producer Luis de Llano Macedo. She won the Best Actress Ariel for "Nosotros," an episode of the multi-part film _Tú, yo, nosotros (1970)_ (ironically, one of the other actresses nominated was her daughter, Julissa); Macedo also earned a Best Supporting Actress Ariel nomination for La vie criminelle d'Archibald de la Cruz (1955).