His professional work in film began in 1998, when he co-wrote and played the lead role in the award-winning Pi, directed by longtime collaborator Darren Aronofsky. He has since played principal and supporting roles in some twenty films. He directed his first feature film, Traitors, starring Chaimae Ben Acha and Soufia Issami, which made its world premiere at the 2013 Venice Days festival, and screened in competition at the Stockholm Film Festival and at the Marrakech International Film Festival, the Dubai Film Festival, and the Tribeca Film Festival. The film is distributed internationally by Rezo Films, Paris. Gullette was announced at the Cannes Film Festival as the writer-director of Tangier, a film in-development set to star Kristin Scott Thomas and Jeremy Irons. Tangier will be produced by Darren Aronofsky's Protozoa Pictures. Gullette is also attached to the project Nip the Buds Shoot the Kids, based on the novel by Kenzaburo Oe.