Zachary Webber was born in Fort Worth, Texas to Paul Webber, a professor of quantitative finance and mathematics, and Tammara Webber, a novelist. He is a graduate of New York University. He performed on many stages in New York City while a student, including Radio City Music Hall, The Harlem School of the Arts, Upright Citizens Brigade, and PS 122. His film work includes In a Relationship (2015) with Dakota Johnson, Ithaca (2015) with Sam Shepard, Running Wild (2015), and Shut Up and Drive (2015). He is a member of the online sketch comedy group Sasquatch with Jack Quaid, Danny Jolles, and Nick Williams.