The youngest of four siblings, Brian George was born in Jerusalem to Jewish parents in July 1952. Both of his parents had immigrated to Israel from India. His father was born in Iraq but raised in Bombay and his mother was born and raised in India. When Brian was a year old, the family immigrated to London. Brian attended an all-boys school in London. In 1966, the family moved to Toronto and he attended public high school, followed by the University of Toronto, where he became involved in theater. George left before graduation and formed an unsuccessful theater group. He joined The Second City, where he trained with comedy greats including John Candy, among others. His career in acting and voice-over work has flourished ever since.