The Brain is a supervillain. He is an enemy of the Teen Titans and the Doom Patrol.As a scientist, the Brain experimented on animals to raise their intelligence. One of his experiments was when he captured a gorilla and experimented on it, raising its I.Q. to the genius-level of 178. He named the gorilla Monsieur Mallah and educated him for almost a decade before making him his personal assistant.His colleague grew jealous of his work and arranged for the scientist to get caught in an explosion, which destroyed the scientist's body. Only the brain survived.Mallah rescued the scientist, taking his brain and transferring it to a computer network that kept it functioning.Now known as the Brain, the scientist and Mallah gathered together the criminal organization known as the Brotherhood of Evil in hopes of conquering the world. The Brain, Mallah, and their Brotherhood became enemies of the Doom Patrol. Their criminal activities would also pit them against the Teen Titans.