Vanessas vital spirit and pleasure-loving nature were ill-suited to convent life. With da Vincis help, Vanessa escaped the strict religious environment, to which shed been confined as a girl, and happily chose to earn a living as barmaid and model. Vanessa is properly valued by the world in general, and Nico in particular for her sunny disposition and her exquisite beauty.She had a romantic relationship with Guliano di Medici. Later she got pregnant by him. After his death, she told his brother Lorenzo de' Medici about Guiliano's child. After that, Lorenzo's wife Clarice Orsini brought Vanessa into the Medici household, where she became a virtual prisoner with few of the liberties she valued before. Nevertheless she helps Clarice to maintain control over the board of the Medici bank. But then she catches Clarice having sex with her uncle in law Carlo. Carlo's eyes meet hers before she walks away.Vanessa is furious when Carlo murders Andrea and flees, confronting Clarice about her affair with him. Shortly after she enters labor and gives birth to a son, thereby giving the House of Medici a needed male heir. When Clarice has to flee because of Carlo's crimes, Vanessa's son is the only Medici in Florence, Vanessa is made de facto ruler of the city.