Dr. Meredith Grey : [about her PVS patient]  But he was looking *at* me. Dr. Derek Shepherd : He wasn't looking at you. Dr. Meredith Grey : He was. Dr. Derek Shepherd : The CT report says he wasn't. Dr. Meredith Grey : Do you wanna argue with what I know I saw? Dr. Derek Shepherd : No, Meredith, I don't want to argue with you any more.

Dr. Meredith Grey : Goodbye, Derek. Dr. Derek Shepherd : Goodbye, Meredith.

Dr. Derek Shepherd : I'm cooking the trout outside the trailer. Dr. Addison Shepherd : I still hate the freaking trailer.

Dr. Derek Shepherd : Do you happen to know what time of year neurosurgeons are the busiest, Dr. Stevens? Dr. Isobel "Izzie" Stevens : There's a time of year? Dr. Derek Shepherd : There's no hard or fast rule, but brain injuries tend to pile up around the holidays. Like our friend here. Folks fall off their roofs while they string up lights. Or they go skating for the first time in a decade and break their heads open. And every year people drive through blizzards to get to parties where they kiss germ-infected strangers under poisonous mistletoe. And then they get so drunk that they smash their heads through their windshield on their way home. Like I said, there's no hard or fast rule.

Dr. Derek Shepherd : I am not mentally challenged. Dr. Miranda Bailey : I'm not so sure about that.

Dr. Addison Shepherd : I hate this freaking trailer! Dr. Derek Shepherd : Fine then. No trout for you.

Dr. Meredith Grey : What was I to you? The girl you screwed to get over being screwed? Dr. Derek Shepherd : You were like coming up for fresh air. It's like I was drowning and you saved me. It's all I know. Dr. Meredith Grey : It's not good enough.

Dr. Derek Shepherd : [to a patient and rapist whose victim bit off his penis]  I have good news and bad news. The good news is that we managed to stop the bleeding. The bad news is that we gave your penis to the cops.

Dr. Meredith Grey : You're my teacher's teacher. And my teacher. Dr. Derek Shepherd : I'm your sister. I'm your daughter.

Dr. Derek Shepherd : It's not the chase. Dr. Meredith Grey : What? Dr. Derek Shepherd : You and me. It is not the thrill of the chase. It's not a game. It's... it's your tiny ineffectual fists. And your hair. Dr. Meredith Grey : My hair? Dr. Derek Shepherd : It smells good. And you're very, very ballsy. It keeps me in line. Dr. Meredith Grey : I'm still not going out with you. Dr. Derek Shepherd : You say that now...

Dr. Derek Shepherd : [to Addison]  Christmas makes you want to be with people you love. I'm not saying this to hurt you, or because I want to leave you, because I don't. Meredith wasn't a fling. She wasn't revenge. I fell in love with her. That doesn't go away because I decided to stay with you.

Dr. Derek Shepherd : So we're kissing but we're not dating? Dr. Meredith Grey : I knew that was going to come up. Dr. Derek Shepherd : Don't get me wrong: I like the kissing. I'm all for the kissing. More kissing, I say. Dr. Meredith Grey : I have no idea what that was about. Dr. Derek Shepherd : Is it going to happen again? 'Cause if it is, I need to bring breath mints. [whispers]  Dr. Derek Shepherd : Put a condom in my wallet. Dr. Meredith Grey : Shut up, now!

Dr. Meredith Grey : Did you let me scrub in for this operation because I slept with you? Dr. Derek Shepherd : Yes. [pause]  Dr. Derek Shepherd : Just kidding.

Dr. Meredith Grey : Don't look at me like that. Dr. Derek Shepherd : Like what? Dr. Meredith Grey : Like you've seen me naked!

Dr. Mark Sloan : You're a bad liar. Dr. Derek Shepherd : You're old.

Dr. Derek Shepherd : So, who's next, Alex? He likes to sleep around... you two have that in common. Dr. Meredith Grey : You don't get to call me a whore! When I met you, I thought I had met the person I would spend then rest of my life with. I was done. So all the boys, and all the bars, and all the obvious daddy issues... who cared? Because I was done. You left me! You chose Addison! I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore!

Dr. Derek Shepherd : It's a beautiful day to save lives. Let's have some fun.