Dr. Isobel "Izzie" Stevens : You said before, *I am not your sister*. Do you feel like I was emasculating you? Dr. George O'Malley : No. I'm too masculine to be emasculated. Dr. Isobel "Izzie" Stevens : I'm sorry. Dr. George O'Malley : Guess you put Dr. Model to rest? Dr. Isobel "Izzie" Stevens : Guess I did.

Dr. George O'Malley : Uh, Mr. Mackie I can't go out with you. You're not my type, I mean, you're a guy. Lloyd Mackie : George, I knew you weren't gay.

Dr. George O'Malley : I think you're taking some risks. I think you'll find yourself in some guy's basement being ordered to put the lotion on the skin or you'll get the hose again.

Dr. George O'Malley : This shift is a marathon, not a sprint. Eat. Dr. Isobel "Izzie" Stevens : I can't. Dr. George O'Malley : You should eat something. Dr. Isobel "Izzie" Stevens : You try eating after performing 17 rectal exams. The Nazi hates me. Dr. George O'Malley : The Nazi's a resident. I have attendings hating me.

Dr. George O'Malley : [talking to himself]  Oh, hi, chief. Nope, not much going on, well, other than your intern chief making out with my friend in the stairwell, but hey... sponge duty sucks. Dr. Meredith Grey : [walks up beside him]  Talking to yourself now? Dr. George O'Malley : Yes. No. [pause]  Dr. George O'Malley : Damn it. I'm a bad sponge. A leaky sponge. I'm gonna leak all the wrong secrets. I'm a bad liar. I can't even lie about talking to myself.

Dr. George O'Malley : I don't think you understand. Me - gonads! You - ovaries! Dr. Isobel "Izzie" Stevens : Oh, that reminds me. We are out of tampons. Dr. George O'Malley : You're parading through the bathroom in your underwear, while I'm naked in the shower! Dr. Isobel "Izzie" Stevens : Will you add it to your list, please? Dr. George O'Malley : What? Dr. Isobel "Izzie" Stevens : Tampons! Dr. Meredith Grey : To the list. It's your turn. Dr. George O'Malley : I am a man! I don't buy girl products. I don't want to see you walking in while I'm in the shower. And I don't wanna see you in your underwear! Dr. Isobel "Izzie" Stevens : It doesn't bother me, okay? Look at me in my underwear, George. Take your time, it's no big deal.

Dr. George O'Malley : Do you remember when he wallpapered the hospital with pictures of you in your underwear? Dr. Isobel "Izzie" Stevens : Yeah. Yeah, I do. Dr. Alex Karev : It was before I knew you.

Dr. George O'Malley : [to Alex]  You gave me syph!

Dr. Meredith Grey : I am an evil mistress. Dr. George O'Malley : But still... you look nice.

Dr. Isobel "Izzie" Stevens : Here, my share of the grocery money. When are you going? Dr. George O'Malley : Tonight. Dr. Isobel "Izzie" Stevens : Okay. Seriously, George. Please don't... Dr. George O'Malley : Yeah, could we not talk about it here? Dr. Isobel "Izzie" Stevens : What? Tampons? Dr. George O'Malley : Did you not hear a word I said? Dr. Isobel "Izzie" Stevens : You're a man, we know. [everyone in the room starts to laugh]  Dr. Alex Karev : Talk about shrinking the salamander.

Dr. Cristina Yang : Even George manages to get some action. Dr. George O'Malley : Correction: George got some syphilis.

Dr. George O'Malley : There needs to be some rules. Dr. Meredith Grey : So, what we can walk around in our underwear on alternate Tuesdays? Or you could see bras, but not panties? Or are you talking Amish rules? Because if you think you're gonna get Izzie to cover herself... Dr. George O'Malley : The amount of flesh exposed is not the point. You have to do something, it's your house. Dr. Meredith Grey : It's my mother's house. Dr. George O'Malley : Meredith! Dr. Meredith Grey : Do you like Izzie? Is that was this is about? You have a crush on Izzie? Dr. George O'Malley : Izzie? No! I don't like Izzie. Izzie? No! She's not the one I'm attracted to. Dr. Meredith Grey : Not the one. So there's a one? Dr. George O'Malley : Look, there just have to be some rules.

Dr. George O'Malley : I know I'm not a lot of things that you've gone for in the past - I know, but I would never leave you. I would never hurt you. And I will never stop loving you...

Dr. George O'Malley : 007. They're calling me 007, aren't they? Izzie & Meredith : No-one's calling you 007. Dr. George O'Malley : I was on the elevator and Murphy whispered 007. Dr. Cristina Yang : Okay, how many times are we going to go through this, George? Five, ten? Give me a number or else I'm gonna hit you. Dr. George O'Malley : Murphy whispered 007 and everyone laughed. Dr. Isobel "Izzie" Stevens : He wasn't talking about you. Dr. George O'Malley : Are you sure? Dr. Meredith Grey : Would we lie to you? Dr. George O'Malley : Yes!

Dr. Alex Karev : So, Grey and Stevens really walk around in their underwear? Dr. George O'Malley : Um... Not all the time. I mean, some of the time. But not all the time. Dr. Alex Karev : Sexy underwear? Dr. George O'Malley : Yeah... Dr. Alex Karev : And they just let you look at them? Dr. George O'Malley : Well, uh... yeah. Dr. Alex Karev : Like sisters? Dr. George O'Malley : No! Not like sisters. Uh... no! I don't think of them like sisters. Dr. Alex Karev : But they're no coming on to you? Dr. George O'Malley : Not exactly. Dr. Alex Karev : They don't expect you to do anything. Dr. George O'Malley : No, but... Dr. Alex Karev : Like sisters. Just like sisters.

Dr. Isobel "Izzie" Stevens : [standing in the bathroom, outside the shower, where George is]  I reminded you before you went. Dr. George O'Malley : I forgot when I got there. Dr. Isobel "Izzie" Stevens : No. [she opens the shower door]  Dr. Isobel "Izzie" Stevens : No, you were so passive aggressive! Dr. George O'Malley : Naked! I am naked in the shower! Dr. Isobel "Izzie" Stevens : [closes the shower door]  Just tampons, George! I really needed tampons. God! [Meredith enters the bathroom]  Dr. Isobel "Izzie" Stevens : I'm not riding in the same car as him. Dr. Meredith Grey : [looks at Izzie, who is standing in her "Hello Kitty" underwear]  Unless you're going like that, you're not riding with me either. Where are the tampons? Dr. Isobel "Izzie" Stevens : He didn't buy them. Dr. Meredith Grey : [to George]  You didn't buy them? Dr. George O'Malley : Men don't buy tampons! Dr. Isobel "Izzie" Stevens : [opens the shower door again, and George falls over]  You know what? You're gonna have to get over the whole man thing, George! We're women! We have vaginas! Get used to it! [she walks out of the bathroom, leaving George lying on the floor of the shower]  Dr. George O'Malley : I am not your sister! [he slams the shower door] 

Dr. Cristina Yang : [about Burke]  He's seen me naked a thousand times. Dr. George O'Malley : Bad! Bad images in my head!

Dr. George O'Malley : You know Joe? Dr. Miranda Bailey : Oh, yeah. I was the only female intern my year. I didn't know anybody and nobody knew me except Joe. He knew me. Dr. George O'Malley : Oh. So you and Joe...? Dr. Miranda Bailey : All you people ever think about is how to get into somebody's pants. You're nasty. [slaps George]  Dr. Miranda Bailey : That's why you got syphilis.

Dr. Cristina Yang : [they all see the Nazi]  That's the Nazi? Dr. George O'Malley : I thought the Nazi would be a man. Dr. Meredith Grey : I thought the Nazi would be... the Nazi. Dr. Isobel "Izzie" Stevens : [Izzie walks up behind them]  Maybe it's professional jealousy. Maybe she's brilliant and they call her a Nazi because they're jealous. Maybe she's nice. Dr. Cristina Yang : Let me guess - you're the model. [Izzie gives her an evil look]  Dr. Isobel "Izzie" Stevens : [to the Nazi]  Hi, I'm Isobel Stevens, but everyone just calls me Izzie. Dr. Miranda Bailey : I have five rules. Memorize them. Rule number one, don't bother sucking up. I already hate you, that's not gonna change.

Dr. Alex Karev : What are you doing? Dr. George O'Malley : Hiding. There's this VIP patient. He likes me. Dr. Alex Karev : Well, that's good, right? Dr. George O'Malley : He *likes me*, likes me. Dr. Alex Karev : Go for it, man. Get yours, I'm down with the rainbow. [George gives him a strange look]  Dr. Alex Karev : Oh, are you not gay? Dr. George O'Malley : No. Dr. Alex Karev : Really? Dude, sorry. [he walks away]  Dr. George O'Malley : [Cristina walks up]  Cristina! Do you... does Meredith think I'm gay? Dr. Cristina Yang : Are you? Dr. George O'Malley : No! Dr. Cristina Yang : Really?